Author(s) Details:
Pablo Hernán Sotelo
Biotechnology Department, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, San Lorenzo 111421, Paraguay.
Arturo Vargas-Correa
Biotechnology Department, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, San Lorenzo 111421, Paraguay.
This section is a part of the chapter: Strategies for Studying Antiviral Activity of Natural Products: From Screening to Mechanism Elucidation
The discovery and development of antiviral agents from natural products have gained significant attention owing to the increasing prevalence of viral infections and the emergence of drug-resistant strains. This chapter explores various strategies for studying antiviral natural products, focusing on methodologies for virus quantification, the design of biosensors for specific targets and approaches for investigating natural products that may impact multiple stages of the viral cycle. Traditional screening methods, such as plaque assays and quantitative PCR, are discussed along with innovative techniques, such as reporter systems and sensor design. This chapter also discusses the design and development of innovative methods for studying specific viral proteins and processes that are essential for viral production. Bioinformatics approaches, such as docking analysis and network pharmacology,are powerful tools for identifying potential inhibitors and elucidating the complex mechanisms of action of natural products. By combining traditional virology techniques with innovative screening methodologies and bioinformatics approaches,researchers can exploit the vast potential of natural products to combat viral infections and accelerate the discovery and development of effective antiviral therapies.
How to Cite
Sotelo, P. H. ., & Vargas-Correa, A. . (2025). Strategies for Studying Antiviral Activity of Natural Products: From Screening to Mechanism Elucidation. Pharmaceutical Science: New Insights and Developments Vol. 4, 1–17. https://doi.org/10.9734/bpi/psnid/v4/4496